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Subsequently, nucleus translocation of PARP1-dependent AIF interacts with macrophage migration inhibitory factor (MIF) to format the AIF-MIF complex, which further induces the DNA breakage and ultimately results in parthanatos [140]

[DOI] [PubMed] [Google Scholar] Gaikwad N.W

In metabolic stress settings, exercise training can restore reduced hepatic PGC-1 expression, consistent with a re-engagement of mitochondrial quality-related programs in the liver (Dethlefsen et al., 2018)

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