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Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

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As previously noted, Gpxs fall into two distinct categories, selenium-dependent Gpxs (Sec-Gpx) and non-selenium-dependant Gpxs (C-Gpx), which have a cysteine in place of the selenocysteine within the catalytic triad (Floh, 2012)

In order to be successfully synthesized in ER, the chaperone GRP78 is induced and activated to promote the refolding process of misfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

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Through microarray profiling of messenger RNA (mRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) expression validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR), their research suggests that immunoregulatory ceRNA (competing endogenous RNA) networks involving lncRNA-circRNA interactions constitute potential therapeutic targets [178]