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The fluorescence of R6G labeled nanocarriers in the cell lysates were measured by spectrofluorometer (Fluorolog 3, Horiba Jobin Yvon, USA) at 525 nm excitation and 551 nm emission wavelengths

The 4-hydroxyphenyl moiety was found to be essential for higher inhibition and 3,5-dihydroxyphenyl or 3,5-dimethoxyphenyl derivatives showed better tyrosinase inhibition than 2,5-dimethoxyphenyl derivatives

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Deficiency of vitamin B12 may cause tiredness, weakness, constipation, loss of appetite, weight loss and megaloblastic anemia (a condition when red blood cells become larger than normal)

The upregulation of these enzymes in models of tissue injury highlights their importance in post-surgical repair processes 6