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Interestingly, as desensitization involves a number of steps including receptor phosphorylation, -Arr recruitment, and internalization or degradation, aberrations at any level may precipitate disease

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77,78 Of note, the amyloid cascade hypothesis remains controversial

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In neutrophils, high concentrations of dopamine (10 4 and 10 5 M) inhibited IL-8 mediated transendothelial migration (Sookhai et al., 2000)