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Parkinsons disease and Parkinsons disease medications have distinct signatures of the gut microbiome

Unlike color deconvolution and color space transformation, which require semi-automated processing, the ML model processed all images autonomously after training

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~ AlphaMD Sildenafilcommonly known by the brand name Viagrais a medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH)

The major methyltransferases are: COMT (catechol-O-methyltransferase) : inactivates catecholamines (dopamine, norepinephrine, epinephrine), catechol estrogens, and catechol drugs (L-DOPA) R HNMT (histamine N-methyltransferase) : the primary intracellular histamine degradation enzyme in the brain and peripheral tissues R INMT (indolethylamine N-methyltransferase) : methylates tryptamine, serotonin, and other indoleamines R NNMT (nicotinamide N-methyltransferase) : methylates nicotinamide (vitamin B3) and other pyridines R TMT (thiol S-methyltransferase) : S-methylates thiol drugs (captopril, D-penicillamine) and thiol metabolites R TPMT (thiopurine S-methyltransferase) : methylates thiopurine drugs (azathioprine, 6-mercaptopurine) used in autoimmune disease and cancer R Methylation capacity depends on the methylation cycle: methionine to SAM-e to SAH to homocysteine, recycled back to methionine by methionine synthase (B12-dependent) or BHMT (betaine-dependent)

Blood Sample Collection: Samples were collected from individuals with normal blood count from the Hematology Lab at the Clinical Chemistry Department at Sahlgrenska University Hospital, Gothenburg, Sweden Lymphoprep (Axis-Shield PoC AS, Oslo, Norway) was used to harvest peripheral blood mononuclear cells (PBMCs) via density gradient-based separation