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Despite its exclusive synthesis in the cytosol, GSH is distributed in intracellular organelles, including the endoplasmic reticulum (ER), nucleus, and mitochondria (Fig

Results Fragment-based drug design and chemistry Utilizing actives identified in a quantitative high-throughput screen against Schistosoma mansoni TGR 20,35 , 92 commercially available low molecular weight (MW) compounds/fragments were tested by X-ray crystallography 33,34,36

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Apoptosis is a form of programmed cell death characterized by cell and nuclear shrinkage while maintaining membrane integrity (Li et al., 2020)

For co-IP, the cleared cell lysate was incubated with 10 g His-tagged N0362 protein for 3 h at 4 C

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