glutathione and longevity Frontiers Glutathione and Longevity: The Antioxidant

Key Points Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain The avascularity of the IVD is an obstacle to intrinsic repair by exogenous cells Tissue-specific progenitor cells have been identified in the IVD, and these cells could be targeted to promote intrinsic repair Supplementation of functional cells from exogenous sources has IVD-regenerative effects in basic and preclinical studies A growing number of clinical trials are assessing the effects of cell therapy for IVD disease Despite promising results of cell therapy for IVD disease in preclinical studies, various obstacles remain to define its efficacy and target indications Abstract Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain, which accounts for disability worldwide

A similarly acting drug developed by the pharmaceutical company Pfizer, named CE, confirmed this finding by testing rats at an even longer delay than previously investigated with Rimonabant, and also found enhanced spatial memory consolidation

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doi:10.1038/srep37664 Li H, Low YSJ, Chong HP, et al

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Biochim Biophys Acta BBA General Subj 1379(2):233244 Miron T, Rabinkov A, Mirelman D, Wilchek M, Weiner L (2000) The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity