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Deficiency states may be secondary to either a lack of thiamine in the diet or the presence of thiamine destroying compounds in the diet (e.g., bracken fern, raw fish, amprolium, thiaminase-producing bacteria in ruminants)

Comment: Most commenters were supportive of the replacement of the OASIS-based DTC measure with the claims-based DTC-PAC measure

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Plasma glutamate concentrations peaked about twice as high as baseline and placebo

These research applications continue in laboratory settings to characterize mechanisms and optimize experimental protocols for NAD+-based investigations