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The other common polymorphism involves a Leu substitution in place of the more common Pro at amino acid 198 due to a substitution of T (codon, CTC) for a C (CCC)
62 Recent data presented at ESMO 2023 also showed an overall survival (OS) benefit with dostarlimab added to chemotherapy in the MMR-D/MSI-H group, HR 0.30 95% CI 0.1270.699
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Adv Exp Med Biol 1164:7387 Yokoyama A et al (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics
Proline interacts through hydrogen bonds with the GSH-cysteinyl moiety's backbone amine group
