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The therapy for people with Parkinsons also focuses on the underlying mental symptoms via infusions of progenitor cells that can release dopamine, which then raises the levels of new neuron cells needed to slow down, stop, or, in some cases, reverse the gradual progression of Parkinsons before its too late

It was indeed tempting to accept the relatively straightforward assumptions that (i) CDDP would exert antineoplastic effects by binding one (or a few) molecular target(s), hence activating relatively simple signaling pathways, and (ii) that CDDP resistance would originate from the activation of mutually exclusive mechanisms

Indeed, an element of this redundancy may stem from Retromers hub-like ability to regulate several RABs linked to endosomal cargo recycling

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Multiple parallel hits have been postulated to explain the complex molecular pathogenesis underlying the evolution from NAFLD to NASH [6]
