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Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

Adenylyl cyclase and phospholipase C are activated by different types of G proteins, allowing cells to couple the production of the small molecules to different extracellular signals

Gai inhibits adenylyl cyclase, which decreases cAMP (cyclic AMP) levels

Nat Immunol 15:707716 Li M, Zhao L, Zhang C et al (2018) Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors