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Yellowing of the cake, collapse of the lyophilized structure, or cloudiness after reconstitution are late-stage signs of advanced degradation, not early warning signals

These Trm cells likely arise from Tmp cells that enter tissues and acquire additional programs of long-term tissue residency that include the ability to provide local protective immunity 10, 11, 12

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S.DriesenK.Dukes-RimskyL.PrestonG.et al (2023)