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The Danger: If the body creates antibodies against exogenous DSIP, these antibodies might cross-react with endogenous DSIP (or DSIP-like proteins/GILZ)

Lipid Synthesis Glutamine-derived -ketoglutarate converts to acetyl-CoA, which supports lipid formation

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Folate deficiency during this period is associated with the development of autism spectrum disorders in children, neural tube irregularity, and brain development defects in the fetus and brain function in later life (, , , , )

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Even short periods of immobilization of the PIPJ may lead to permanent loss of function