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Metformin is able to decrease inflammatory indicators such as myeloperoxidase and malondialdehyde by promoting the classic AMPK signalling pathway to inhibit apoptosis induced by LPS and TNF-, thus mitigating liver damage [184,185]

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To clarify gut microbiota interventions' efficacy in alleviating depressive symptoms, researchers did systematic reviews and meta-analyses, including RCT on probiotics, prebiotics, synbiotics or fecal microbiota transplantation in adults (18 years) that used validated, placebo-controlled measures to assess depressive symptoms

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