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The activated Trem2 signal in stage 1 DAM facilitates transition to stage 2 DAM, which is characterized by an upregulation of lysosomal, phagocytic, and lipid metabolism pathway-related genes including cst7 and itgax
403 MTK458 binds to PINK1 and stabilizes the PINK1TOM complex, promoting the clearance of accumulated pUb and Syn pathology both in vitro and in vivo
N Engl J Med 352(10):987996
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Archives of Pharmacal Research, 30 (7), 834839
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