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Another reason for the reduction in antioxidant defenses could rely on the high lipid content found in maternal blood, during twin pregnancies [213]

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However, the detected deficits are in good agreement with the here observed hippocampal hypometabolism and synaptic alterations in the hippocampus of Tg4-42 mice 22

However, ascorbic acid can also be a pro-oxidant in the presence of metals such as iron and copper triggered by Fentons reaction (Buettner, 1993

doi: 10.1124/jpet.102.040220

Examples of drugs that can cause interactions with methotrexate are listed below