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The development of mitochondria-targeted drug delivery systems should improve selectivity and therapeutic efficiency while minimizing unintended side effects

Arterioscler Thromb Vasc Biol 26(12):26142621 Andersson DC et al (2011) Mitochondrial production of reactive oxygen species contributes to the beta-adrenergic stimulation of mouse cardiomycytes

Transcriptome and lipid Metabolomics-Based discovery: Glycyrrhizic acid alleviates tripterygium glycoside tablet-induced acute liver injury by regulating the activities of CYP and the metabolism of phosphoglycerides

doi: 10.1203/PDR.0b013e31819ed5c8

This is also accompanied by only a 25% reduction in the NADPH:NADP + ratio [61]

In the post-treatment group (injected with cisplatin first, and then receiving -lipoic acid at 100 mg/kg for the next two days), alleviation of hearing loss was also observed, although a small difference in auditory brainstem response threshold changes was observed between the pre- and post-treatment groups