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In conditions of progressive NAFLD, OS can also result from increased ROS generation due to impairment of mitochondria caused by an overload of FFAs and an increase of their metabolism, lipotoxicity, and hypoxia, as well as ROS production through NADPH-oxidase isoforms associated to ligandreceptor link or by activated inflammatory cells (49)

Notably, the key factors regulating lipid peroxidation and ferroptosis are either target genes of AhR or are regulated by AhR target genes

3f), but with a circadian shift compared to the same mice measured 6 months before (Supplementary Fig

To visualize the parasite nuclei, ProLong Gold Antifade Mountant with DAPI (Invitrogen) was applied to the slides and incubated at 37C for 30 min in the dark

doi: 10.1016/j.freeradbiomed.2004.06.026

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