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Before taking a B12 shot, tell your doctor if you: Are allergic to B12, cobalt or any multivitamin combinations Have vision issues or Lebers disease (a genetic condition that causes vision loss) Have any infections Have been diagnosed with folic acid deficiency or iron deficiency Are pregnant, breastfeeding, or planning to get pregnant Are taking any supplements, including herbal supplements Are taking any medications, such as folic acid, methotrexate, chloramphenicol, colchicine, para-aminosalicylic acid (PAS), or pyrimethamine Have liver or kidney disease Have a drinking problem Health News Are Microplastics Linked To Higher Heart Attack Risk

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That all indicates to me that if you reach a B12 intake level that gives you coloured wee...you just scale back a bit

In line with this idea, high expression of NNMT is related to lower triglycerides and serum cholesterol, both in mice and humans [51]