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theorizing its interaction with brain reward dysregulation, addictive behavior, and aging

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I.de HozR.Salobrar-GarciaE.SalazarJ

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These strategies encompass low-dose interleukin-2 therapy to selectively expand Tregs, the adoptive transfer of ex vivo-expanded Tregs, and the modulation of immune checkpoints to counteract Treg exhaustion (12, 13)

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They are connected by a flow of glutamine (produced directly from glutamate, generated as discussed below) from astrocytes to neurons

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Further complexity into the uptake of metabolites affecting methyl group metabolism is added when considering sex-specific differences in the availability of key metabolites caused by sex hormones

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Photosynthetica 46:410419 Meister A (1995) Glutathione biosynthesis and its inhibition

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