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theorizing its interaction with brain reward dysregulation, addictive behavior, and aging

I.de HozR.Salobrar-GarciaE.SalazarJ
These strategies encompass low-dose interleukin-2 therapy to selectively expand Tregs, the adoptive transfer of ex vivo-expanded Tregs, and the modulation of immune checkpoints to counteract Treg exhaustion (12, 13)
They are connected by a flow of glutamine (produced directly from glutamate, generated as discussed below) from astrocytes to neurons

Further complexity into the uptake of metabolites affecting methyl group metabolism is added when considering sex-specific differences in the availability of key metabolites caused by sex hormones

Photosynthetica 46:410419 Meister A (1995) Glutathione biosynthesis and its inhibition
