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While semaglutide remains the most common prescribed compounded molecule, the share of tirzepatide is increasing over time

In studies with rats, the active ingredient tirzepatide and medicines that work like tirzepatide have caused thyroid tumors, including thyroid cancer

Insulin resistance could be restored by thyroid hormone replacement (75, 76)

More potent than its predecessors, retatrutide activates three receptorsGLP-1, GIP, and glucagonas opposed to only one (as is the case with semaglutide) or two (like tirzepatide)