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Mechanistically, SGLT2 inhibitors enhance podocyte autophagy by suppressing mTORC1 activity and reduce NLRP3 inflammasome-mediated inflammation, thereby preserving synaptopodin expression and podocyte integrity

Acknowledgements This work was supported by the Swedish Brain Foundation (grant FO2023-0241), the Swedish Research Council (VR-NT grant 2022-04198, VR-TVAR 2021-03293), and the Science for Life Laboratory (all to P.E

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219 Although progress in developing specific IC/BPS treatments has been slow, these are exciting times for the development of new treatment targets

It has been used in clinical trials for ulcerative colitis and multiple sclerosis, and has shown consistent healing effects on various wounds, including skin, muscle, tendon, ligament, bone, and ulcers in the entire gastrointestinal tract

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