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Clinical and animal studies have demonstrated that a major physiological consequence of total parenteral nutrition is the loss of intestinal barrier integrity.52 Mice administrated with total parenteral nutrition show increased intestinal paracellular permeability and decreased levels of TJ proteins, which is reversed by IL-10 treatment.53 Collectively, IL-10 restores the intestinal barrier defect

Our screening workflow is schematically presented in Figure 2A and illustrated as follows

Although more studies are needed to provide a conclusive effect of GLP-1 receptor agonists on peripheral neuropathy, studies have shown that among participants with type 2 diabetes mellitus receiving exenatide treatment, a significant increase in corneal nerve branch density ( p = 0.02) and vibration perception threshold was observed [52]

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