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They then metabolize Thr to formate, which is transported to the cytosol where it is converted to S -adenosyl methionine (SAM), methyl group donor required for H3K4 methylation in the nucleus (Figure 1)

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Administrated resveratrol positively affects the synthesis of sirtuins, SIRT1 (a family of proteins NAD + -dependent histone deacetylases playing an important role in the regulation of metabolic pathways, see below) activating then superoxide dismutase 2 (Mn-SOD) expression in cardiomyocytes and improved cardiac functions (Tanno et al