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Compounding pharmacies recognized these patterns and began including B12 as a preventive measure

These patients may experience a blunted or impeded response to the intranasal medication

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After that, many patients shift to monthly doses for maintenance

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Pongcharoensuk and Thaiwat [88] reported a case of systemic, pigmentary, contact dermatitis (confirmed by histopathological examination) that occurred in a 55-year-old woman during a three-month oral supplementation of vitamin B12 (600 g/day) due to neuropathic pain