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Am J Physiol Lung Cell Mol Physiol 301: L353360, 2011

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This superoxide is readily converted into hydrogen peroxide by superoxide dismutase (SOD) either in the cytosol (SOD1), inside mitochondria (SOD2) or outside the cell (SOD3)

Thereby, the application of NO-agents, NOS-blockade L-NAME, NO-over-activity (L-arginine, NOS-substrate) and their relationships (opposite or parallel activities, mutual counteraction or not), which can cover all essential points of NO-system, and the full spectrum of NO-system functions was combined with BPC 157 application to show its full efficacy on maintaining and/or reestablishing NO-system effects and functions [124,125]