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In this study, we reveal a cysteine-reactive covalent ligand EN25 that covalently targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL, leading to inhibition of GCL activity, lowering of cellular GSH levels, and impaired cell viability in ARID1A-deficient cancer cells that are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells

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Glutathione is considered the "master antioxidant." It not only fights free radicals and supports the body's detoxification pathways, it also helps to replen

Eye drops that claim to change a person's eye color are being promoted online, and the ability to do this may sound tempting

Organelle transporters define metabolic compartmentalization and how this metabolite transport process can be modulated is poorly explored

Long Haul Coronavirus (COVID-19) can be effectively treated by addressing the underlying pathophysiology