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After the initial screening, 28 were included in the study and were randomly assigned to either an l-carnitine or a placebo supplementation group (Figure 1)

Quantification of carnitine and specific acylcarnitines by high-performance liquid chromatography: application to normal human urine and urine from patients with methylmalonic aciduria, isovaleric acidemia or mediumchain acyl-CoA dehydrogenase deficiency

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As with any supplement, individuals with medical conditions or those taking medications should consult a healthcare professional before use

However, a randomized controlled trial by Donnell et al