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Consequently, certain pro-inflammatory cytokines and neurotransmitters can penetrate the compromised BBB and affect the central nervous system, thereby exacerbating symptoms via persistent neuroinflammation and neurotransmitter dysregulation ( Figure 1 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Pujol A., Ferrer I., Camps C., Metzger E., Hindelang C., Callizot N., Ruiz M., Pmpols T., Girs M., Mandel J.L

Development by self-digestion: molecular mechanisms and biological functions of autophagy

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