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The findings from monkeys and rodents will now be described and their translatability to one another, and to human studies, will be discussed

[10] Long-term use of proton pump inhibitors (PPIs) and H2-receptor antagonists reduces gastric acid, potentially impairing the release of B12 from dietary proteins

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Most people get enough B12 from their diet, but many have absorption issues that mean adequate intake doesnt translate into adequate cellular levels