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We utilized the procedure recommended by the Cochrane Handbook for Systematic Reviews of Interventions for searching and selecting studies (Higgins et al., 2021)

Two of the most used ESAs for treating anemia in CKD patients are recombinant human erythropoietin and darbepoetin alfa

In the gut, the L-carnitine is metabolized into a compound called Trimethylamine N-oxide (TMAO)

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to the best of our knowledge, no other studies addressed the effects of l-ARG supplementation in patients with severe ED of any etiology, and, particularly, no studies specifically focused on severe ED of vasculogenic etiology, by excluding different forms of disease