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By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, allowing more substrate to enter the NAD+ salvage pathway

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targeted the IP3 receptor (IP3R) channels and induced the downstream pro-apoptotic Ca 2+ -signaling pathway via synthesizing a peptide named Bcl-2 IP3 receptor disrupter-2 (BIRD-2) mimicking the structure of the BH4 domain of Bcl-2