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Acknowledgements The authors thank Nick Rhodes from the Queensland Cyber Infrastructure Foundation (QCIF), Haojing Shao, and Enya Hermsen for their advice on bioinformatical analyses and computational assistance, Alastair McEwan and Mathias Jnsson for their editorial assistance on early drafts of the manuscript, and all members of the Degnan lab for their valuable discussions

[DOI] [PMC free article] [PubMed] [Google Scholar] 208.Sampson T.R., Debelius J.W., Thron T., Janssen S., Shastri G.G., Ilhan Z.E., Challis C., Schretter C.E., Rocha S., Gradinaru V., et al

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Why receptor subtype work matters for interpretation A common question is which receptor subtype is doing the work. A 2025 mechanistic study investigated AMY receptor subtype dependence and reported that cagrilintides body weight lowering effects depended on AMY1R and AMY3R in their models, which provides a more concrete receptor anchored explanation than general appetite language