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10.1152/physrev.00003.2008 31 FengT.WangJ

In HD models, increased mitochondrial fragmentation and impaired clearance have been reported, supporting the possibility of mtDNA leakage as a neuroinflammatory trigger [186]

Metformin is the first therapy for almost everyone with type 2 diabetes, but studies show that the drug creates a risk of vitamin B12 deficiency

The result was presented below in Figure 4

This leads to treatments that fit each patients needs

(5) evidence neuroprotection especially against neuroinflammation, oxidative stress-induced damage and decreased cerebral blood flow
