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As mentioned earlier, the mitochondrial respiratory chain has long been recognized as an effective source of ROS, predominantly O 2

IDO1 and IDO2 are expressed in human tumors: Levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

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2) in Brazil, APL is treated in specialized centers and non-specialized centers, and the incorporation of ATO is relatively new