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However, the process of replication always leaves off a small section from the ends of the DNA strands

doi: 10.1097/00003086-199706000-00034

Psychostimulants, such as methamphetamine, cocaine and synthetic cathinones, disrupt monoaminergic neurotransmission, causing cognitive impairment, psychiatric disturbances, and neurovascular damage

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However, whether sustained NNMT inhibition beyond 12 weeks affects liver function in humans is unknown baseline and periodic monitoring of liver enzymes is recommended for use beyond published trial durations

But these were cardiovascular trials, primarily designed to satisfy the FDA guidance on proving cardiovascular safety, which serendipitously revealed not just safety, but reduced cardiovascular and kidney outcomes with these drugs