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2022;11:e74

it does NOT entirely eliminate the risk

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The abdomen, thigh, or upper arm provide suitable injection sites

77 A Cochrane review of the use of NAC in children with respiratory infections evaluated the safety data from 34 clinical trials, involving 2064 children, and found NAC to be safe, although the authors note that 59 cases of paradoxically increased bronchorrhoea (increased sputum production) in infants under the age of 2 years were reported to the French pharmacovigilance system

Among which, C677T and A1298C polymorphisms of MTHFR have been studied the most in psychiatric diseases and showed significant association with reduction of MTHFR enzymatic activity and methylation