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The intrinsic ferroptosis pathway is completed by directly inhibiting GPX4 activity using compound RSL3, ML210, or FIN56

Those with TEF- OXP1 clone would degrade 5-OP generated from Chac1, while those transformed with empty vector were expected to have 5-OP accumulated

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The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis

MOTS-c plays a role in mitochondrial biogenesis (new cell growth) which enhances cellular energy production and overall mitochondrial function

doi: 10.1089/dna.2018.4541 226 l'HosteSCharguiABelfodilR
