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These fusion proteins enter EpCAM+ cells, and the conjugated toxin inhibits protein synthesis leading to cell apoptosis

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Antioxid Redox Signal 15(2):551589 Devoz PP, Reis MD, Gomes WR, Maraslis FT, Ribeiro DL, Antunes LG, Batista BL, Grotto D, Reis RM Jr, FB, (2021) Adaptive epigenetic response of glutathione (GSH)-related genes against lead (Pb)-induced toxicity, in individuals chronically exposed to the metal

The major disadvantages of the aqueous liquid formulations are microbial contamination, chemical instability of the dissolved drug in aqueous conditions, presence of preservatives that may cause mucosal irritation, and short residence time in the nasal cavity due to mucociliary action [21]

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This observation suggests the involvement of alternative pathways that compensate for the lack of IL-4R