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ADT inhibits the activity of the Androgen Receptor (AR), a ligand-activated transcription factor that belongs to the steroid hormone group of nuclear receptors and is a major driver of CaP growth and progression

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This model suggests a delicate balance between degradation and re-phosphorylation pathways controls the degree of PKC down-regulation after agonist-mediated activation

If no pathogenic mutation is identified, whole genome and whole exome screens are now commonly used to search for potential genetic diagnoses, with new disease genes constantly being identified

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PMID 18226274