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Doxorubicin also increased hepatic IL-6 expression and plasma AST levels, and reduced total body weight

doi:10.1186/s12902-023-01389-0

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A single FOXO4-DRI dose clears accessible senescent cells within the circulation and tissues with high vascular permeability, but deeper tissue reservoirs require time for macrophage-mediated clearance of apoptotic material before a second dose can access previously shielded senescent populations