glutathione pyruvate dehydrogenase Mitochondrial depletion reveals a novel role for the complex as a key H2O2-emitting source under conditions of nutrient overload GLYI and D-LDH play key

Normally, free radical production is balanced with antioxidants, but if the concentration of free radicals gets too high and our antioxidant enzymes and the antioxidants we get in our diet cannot compensate for these radicals, the balance changes in favor of the oxidantsthat is, in a pro-oxidant direction

Samaka, Magda T

Not only are laboratory rats bred to be healthy under standard laboratory conditions, potentially reducing the genetic factors making them susceptible to disease, they are also fed an exceedingly healthy diet [2] and are often largely free of infections, environmental toxins, and other oxidative stress factors associated with ASD in humans

Nutrients 13 , 3013 (2021)

It works by regenerating other antioxidants like Vitamin C and E, which may boost their effectiveness in protecting the skin

10.1021/pr2005555 235