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On this basis, we not only summarized the effect of ferroptosis in the pathophysiological process of IS, but also listed the corresponding drug targets and potential compounds, aiming to provide new therapeutic ideas for reducing post-stroke injury by targeting ferroptosis

Viceversa, in mice fed a high-fed diet inducing weight gain, hepatic steatosis and IR were accompanied by alterations in expression of hepcidin (a protein that regulates iron homeostasis in response to erythropoietic activity) which preceded dysregulation of iron concentrations particularly in liver and visceral adipose tissue, with no effect on serum iron levels (Varghese et al., 2020)

Despite its toxicity to human health and in agricultural production, the levels of Cd in potential agricultural soils and water bodies are increasing, primarily because of agricultural, urban, and industrial activities (Reeves and Chaney, 2008

doi: 10.1186/s13075-015-0856-2 160 YanaiHBanTWangZChoiMKKawamuraTNegishiHet al

In our opinion, the normal human condition has little resemblance to that scenario

Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. Journal of nutrition and metabolism vol