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It should be emphasized that during corticosteroid therapy prolonged for more than 2 weeks, there is a risk of developing adrenocortical insufficiency, which is manifested by the inhibition of ACTH secretion and adrenal atrophy
I examine the emerging evidence that shows the intricate relationship between metabolism, inflammasome activation and type I interferon signalling, and how these processes are at the centre of the battle between virus replication and host metabolic defences

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