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In skin samples from vitiliginous patients, studies show increased levels of D1-like dopamine receptors, AADC, and MAOs (Reimann et al., 2012), while elevated levels of dopamine itself have been found in vitiligo patient skin, peripheral blood, and urine (Morrone et al., 1992

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Dihydroriboflavin has been indicated to have the ability to reduce oxidised Fe in haemoproteins ( Reference Matsuki, Yubisui and Tomoda 58 , Reference Xu and Hultquist 59 ) , which have been implicated in the oxidative damage of cells including reperfusion oxidative injury ( Reference Hultquist, Xu and Quandt 57 )

We speculate that PUFAs and iron are specifically absorbed in the small intestine 32,33,44 , which could be one explanation for small intestinal disease localization and a requirement for GPX4 activity in the small intestine