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These changes are typically related to the weight loss process itselfincluding dietary modifications, dehydration from gastrointestinal side effects, or mild ketosisrather than a direct pharmacological effect of the medication

The transcriptional hepatic effects of GLP-1GIPLani separated clearly from those of Lani and GLP-1GIP, which was also apparent by a robust shift in principal component analysis (PCA) (Extended Data Fig

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Inhibition of this transporter by ertugliflozin results in increased glucose excretion and an overall reduction in BG levels

Clinical trials show that gastrointestinal side effects, including constipation, occur in 2030% of semaglutide users