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In alignment with these substrate shifts, the peak lactate response to intensive exercise is significantly lower during the luteal phase, a phenomenon attributed to reduced lactate appearance rates and slower carbohydrate turnover compared to the follicular phase [103]

The poor clinical outcomes are largely attributed to the tumors intrinsic resistance to therapy, driven by factors such as blood-brain barrier (BBB) impermeability, cellular heterogeneity, and the persistence of glioma stem cells (GSCs)

In multiple human cancer cell lines, depletion of GGCT downregulated HIF-1 at the mRNA and protein levels
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Remarkable enhancement in antibody titers and hormonal levels was observed within 3 months of therapy ( p 0.05) [48]
