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J Appl Physiol (2011) Ruff D, et al
The addition of equimolar or higher concentrations of Cu 2+ to Htt induces oligomerization, along with the rapid reduction of Cu 2+ to Cu 1+ ( 2+ to Cu 1+ , and copper promotes its aggregation, mediated by histidine residues ( Figure 6 schematizes the pathways that lead to symptoms of Huntingtons disease as a consequence of misfolded mutant Htt
They have confirmed levels of metals in many brands of chocolate that exceed California Proposition 65 standards, specifically for lead and cadmium
Of note, the PHM domain contains ~32% homology to DBH (Solomon et al., 2014) including a catalytic core containing Cu H and Cu M domains, each requiring two copper ions for maximal activity (Eipper et al., 1995
Drug Metab Dispos Biol Fate Chem 46(9):13381350
J Neurochem (1999) 72(5):20928
