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Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS
& de Melker, R
This suggests that precise dosing may be less critical than consistent daily administration over an adequate duration
In particular, understanding the degenerative mechanisms beyond DS neuropathology may lead to answers to a number of open research questions: 1 ) What is the genetic risk profile for the development of early-onset AD
Such biomarkers could help identify patients most likely to respond to treatment and could facilitate personalized treatment approaches
