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The most popular supplementation protocol with creatine monohydrate involves loading with 0.3 g/kg/day for 5 to 7 days, followed by a maintenance dose of 0.03 g/kg/day, typically for 4 to 6 weeks

Thiamine supplementation mood and cognitive functioning

Laboratory evaluation included C-reactive protein (CRP), STAT3, and TGF-1 measurement

Contraindications: Individual intolerance to components

In contrast, increased frontal activation and/or normalization of abnormal connectivity have been associated with improvement of pain and of sad mood (Li et al., 2018